A mixed phase lanthanum vanadate in situ induced by graphene oxide/graphite carbon nitride for efficient photocatalytic hydrogen generation

A mixed phase LaVO₄ with high dispersion was in situ induced and implanted in graphene oxide-graphite carbon nitride composite. The obtained nanocomposite (GO–C₃N₄–LaVO₄) showed high and stable photocatalytic activity for hydrogen evolution, which significantly benefited from the improved charge separation and light absorption in the special composite photocatalyst as evidenced by UV–vis spectra, fluorescence spectrum, photocurrent response and electrochemical impedance. The fabrication strategy of mixed phase LaVO₄ in the GO-C₃N₄ provides a new idea for constructing cheap and active organic-inorganic semiconductor photocatalysts for hydrogen generation.     

薄板坯连铸连轧流程专利分析

以Orbit专利分析平台为主要研究工具，从专利文献中抽取专利数量指标和专利质量指标来构建评价薄板坯连铸连轧技术竞争力和企业创新能力的指标体系，结合其他文献研究的成果，从产业发展的实际出发做出分析，系统揭示了自薄板坯连铸连轧技术开发以来的技术进步、专利布局、发展演化、国内外发展现状、技术竞争实力等，有助于在专利文献提供的线索启发下开发新产品、新技术，从而有效提高研发效率。     

Physical Characteristics of Friction Processes in a Columnar Approach-Separation Model with Tangential Force

Protection of Metals and Physical Chemistry of Surfaces - Three-dimensional molecular dynamics (MD) simulation is conducted to understanding the dynamics processes of atomic-scale friction, which...     

Combating Biofilm Associated Infection In Vivo: Integration of Quorum Sensing Inhibition and Photodynamic Treatment based on Multidrug Delivered Hollow Carbon Nitride Sphere

Recently, quorum sensing (QS) inhibitors (QSIs) have been combined with antibiotics to enhance antibiofilm efficacy in vitro and in vivo. However, targeting QS signals alone is not enough to prevent bacterial infections. Drug resistance and recurrence of biofilms makes it difficult to eradicate. Herein, photodynamic therapy (PDT) is selected to unite QSIs and antibiotics. A synergistically antibiofilm system, which combines QSIs, antibiotics, and PDT based on hollow carbon nitride spheres (HCNSs) is envisaged. First, HCNS provides the multidrug delivering ability, enabling QSIs and antibiotics to be released in sequence. Subsequently, multistage releases sensitize bacteria effectively, potentiating the chemotherapeutic effects of the antibiotics. Finally, the integration of QSIs and PDT not only minimizes the possibility of drug resistance, but also overcomes the problem of limited mass and extension of PDT. Even after 48 h of incubation, the bacterial biofilm is obviously inhibited. And its biofilm disperse efficiency exceeds 48% (compared with QSI‐potentiated chemotherapy group) and 40% (compared with PDT group). Besides, the inhibition of the QS system influences phenotypes related to virulence factor production and surface hydrophobicity, which weaken biofilm invasion and formation. Eventually, this system is applied to disperse bacterial biofilm in vivo. Overall, PDT and QS modulation are devoted to eradicate drug resistance and recurrence of the biofilm.     

Health-promoting effects of dietary polysaccharide extracted from Dendrobium aphyllum on mice colon,including microbiota and immune modulation

The health-promoting effects of a polysaccharide (DAP) purified from Dendrobium aphyllum, on mice colon were investigated. The results indicated that consumption of DAP facilitated the differentiation degree of CD4⁺ T cells to Th₁, Th₁₇ and Treg cells; and depressed the differentiation degree to Th₂ cells, since DAP up-regulated IL-6 expression (from 1.08 ± 0.24 to 3.40 ± 0.36). Besides, oral administration of DAP reduced the gastrointestinal transit time from 255 ± 1.21 to 164 ± 0.46 min, decreased the pH from 6.70 ± 0.27 to 5.54 ± 0.31, improved faecal water-binding capability from 59.4% ± 0.35 to 63.5% ± 0.22. Additionally, the increase in four health-promoting short chain fatty acids were observed, which might result from the enrichment of the relative abundance of health-promoting microbiota genera, including Porphyromonadaceae and Ruminococcaceae. The DAP-induced up-regulation of the genus Erysipelotrichaceae might be related to the homeostasis in both Th₁/Th₂ and Treg/Th₁₇.     

Interaction of IL-22/IL-22R1 promotes cell proliferation and suppresses apoptosis of colorectal cancer via phosphorylation of STAT3

Interleukin-22 (IL-22) is a member of IL-10 cytokine family which is expressed in activated T cells predominantly and in activated natural killer cells at lower levels. Previous studies have demonstrated the link between elevated levels of IL-22 and disease severity of psoriasis, Crohn’s disease, rheumatoid arthritis and interstitial lung diseases. However, the function of IL-22 in the development and progression of colorectal cancer (CRC) remains elusive. In this study, we first evaluated the IL-22/IL-22R1 level in CRC patients, and found that tumor tissues have more active expression of IL-22 and IL-22R1 than normal tissues, presenting correlation with the degree of differentiation of tumor tissues. Subsequently, Caspase and cell viability assays were performed on SW-480 cell line which expresses high level of IL-22R1 to examine if the supplementation of IL-22 has an impact on apoptosis and proliferation. In comparison with treatment of 5-FU, supplementation of IL-22 promoted cell proliferation and ameliorated apoptosis. To unveil signal transduction upon activation of IL-22R, we examined the phosphorylation of STAT3 in SW-480 cell line following supplementation of IL-22. The treatment of IL-22 also increased the level of p-Akt, an essential component in PI3K/Akt pathway. Although the link between STAT3 phosphorylation and PI3K/ Akt activation remains to be explored, our study revealed the mechanism underlying the effects of IL-22R activation on apoptosis as well as tumor differentiation, indicating the prognostic value of IL-22/IL-22R.     

Effect of extrusion temperature on mechanical properties of as-extruded Zn–22Al alloys

ABSTRACT

The effect of extrusion temperature on the microstructures and mechanical properties of as-extruded Zn–22Al alloys was investigated in this study. With decrease of extrusion temperature from 350 to 200°C, the elongation of as-extruded Zn–22Al alloys increases remarkably at low strain rate and has no change at high strain rate, which implies that the Zn–22Al alloys extruded at lower temperature exhibit high-ductility behaviour. X-ray diffraction and electron back-scattered diffraction analysis demonstrated that the maximum elongation of Zn–22Al alloys extruded at the extrusion temperature of 200°C can be attributed to the elimination of the lamellar structure and the refinement in grain size of the Zn-rich phase.     

湖南省郴州市饭垄堆北段锡钨多金属矿勘查方法优化

湖南省郴州市饭垄堆北段锡钨多金属矿位于湘南钨锡钼铋多金属成矿带东坡矿田内，成矿地质条件优越，具有很好的找矿前景。根据该矿床地质特征以及已有的地质矿产勘查成果，系统总结了矿区101、102、103号主矿体特征。在此基础上，进一步讨论了该类裂隙充填细脉带型锡钨多金属矿床在勘查过程中探矿工程布置的优化方法：即：①探矿工程不宜按每个矿带单独控制，应对整个赋矿层位进行整体控制；②应对含有毒砂、锡、钨细脉的岩性段进行连续取样化验，既可避免漏矿，又可以为将来工业指标调整后重新圈定矿体提供直接依据。     

PCEC hydrogel used on sustained‐release hyaluronic acid delivery with lubrication effect

Injection of bionic synovial fluid (BSF) is a conventional method to improve the lubricity of artificial joints, but BSF cannot maintain long due to the dilution and degradation of BSF in human body. To prolong the effectiveness of hyaluronic acid (HA), which is the major component of BSF, this study applies a temperature‐sensitive poly(?‐caprolactone)–poly(ethylene glycol)–poly(?‐caprolactone) (PCEC) hydrogel loaded with HA to achieve long‐term lubrication. In addition, Fourier transform infrared, nuclear magnetic resonance analysis, X‐ray diffraction, scanning electron microscopy (SEM), and gel permeation chromatography spectra were used to analyze the structure of the synthetic hydrogel. Rheological test and test tube inverting method were used to characterize the thermosensitivity. The lubrication properties of the released solution were characterized by UV–vis, tribological tests, SEM, and 3D laser confocal scanning microscope. The experimental results reveal that the triblock PCEC hydrogel contains both hydrophilic block and hydrophobic block, and both PCEC and PCEC/HA hydrogels have phase‐changed effect when the temperature increases from room temperature to body temperature. Moreover, the friction coefficient of the released solution from PCEC/HA hydrogel is approximatively 38% lower than that of phosphate buffer saline. And the ability of shear resistance and creep recovery of PCEC/HA hydrogel are better than that of PCEC hydrogel. This study provides an effective approach to achieve long‐time lubrication effect for artificial joints. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46228.